Exposure to ionizing radiation produced radiation sickness that is a collection of short- and long-term complications. The aim of the present study was to investigate the potential neuroprotective effect of melatonin (MLT) on radiation-induced cell death and hippocampus injury. Rats were divided into seven groups namely control, two melatonin treated groups (MLT-1 and MLT-7) treated with melatonin for one and 7 days, two irradiated groups (Rad-1 and Rad7) sacrificed after one and seven days respectively, and two melatonin treated and irradiated groups (MLT-Rad-1 and MLT Rad-7) sacrificed after one- and seven-days post irradiation. Control rats did not receive any treatment. Melatonin treated groups were injected melatonin at a dose of 10mg/kg. Rats in the Irradiated groups, rats were subjected to a single dose of 4Gy γ-radiation from cobalt-60 source. The present results showed that melatonin protected against body weight loss, nestin up-regulation and protected the histological structure of the hippocampus against irradiation. This will enable to the development of radio-preventive strategies for human under radiotherapy as well as occupational and professional exposure to ionizing radiation.
Ghazala, S., Shabana, S., & Elmisiry, M. A. (2019). Effect of melatonin on gamma radiation-induced brain damage in rats. Journal of Environmental Sciences. Mansoura University, 48(4), 144-148. doi: 10.21608/joese.2019.177052
MLA
Sara Ghazala; Sameh Shabana; Mohamed A. Elmisiry. "Effect of melatonin on gamma radiation-induced brain damage in rats". Journal of Environmental Sciences. Mansoura University, 48, 4, 2019, 144-148. doi: 10.21608/joese.2019.177052
HARVARD
Ghazala, S., Shabana, S., Elmisiry, M. A. (2019). 'Effect of melatonin on gamma radiation-induced brain damage in rats', Journal of Environmental Sciences. Mansoura University, 48(4), pp. 144-148. doi: 10.21608/joese.2019.177052
VANCOUVER
Ghazala, S., Shabana, S., Elmisiry, M. A. Effect of melatonin on gamma radiation-induced brain damage in rats. Journal of Environmental Sciences. Mansoura University, 2019; 48(4): 144-148. doi: 10.21608/joese.2019.177052